Mr. Masjedizadeh et H. Parnes, SYNTHESIS OF TRITIUM-LABELED (R)-3-AMINOQUINUCLIDINE AND (S)-3-AMINOQUINUCLIDINE - A UBIQUITOUS COMPONENT OF SEROTONIN RECEPTOR LIGANDS .1., Journal of labelled compounds & radiopharmaceuticals, 38(1), 1996, pp. 41-51
Citations number
14
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
(R) and (S)-3-aminoquinuclidines-H-3 with the specific activity of 35
Ci/mmol were prepared. Reduction of enamide 2 with carrier free tritiu
m gas over RhCODCl dimer, (2S, 3S) Chiraphos in methanol gave racemic
amide 9c. Hydrolysis followed by resolution of the enantiomers with (R
)-methyl benzyl isocyanate gave (R) and (S)-3-aminoquinuclidine-H-3 10
c-S and 10c-R. The enantiopurity purity of both isomers was >99.5%.