SYNTHESIS OF TRITIUM-LABELED (R)-3-AMINOQUINUCLIDINE AND (S)-3-AMINOQUINUCLIDINE - A UBIQUITOUS COMPONENT OF SEROTONIN RECEPTOR LIGANDS .1.

Authors
MASJEDIZADEH MR PARNES H
Citation
Mr. Masjedizadeh et H. Parnes, SYNTHESIS OF TRITIUM-LABELED (R)-3-AMINOQUINUCLIDINE AND (S)-3-AMINOQUINUCLIDINE - A UBIQUITOUS COMPONENT OF SEROTONIN RECEPTOR LIGANDS .1., Journal of labelled compounds & radiopharmaceuticals, 38(1), 1996, pp. 41-51
Citations number
14
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
38
Issue
1
Year of publication
1996
Pages
41 - 51
Database
ISI
SICI code
0362-4803(1996)38:1<41:SOT(A(>2.0.ZU;2-4
Abstract
(R) and (S)-3-aminoquinuclidines-H-3 with the specific activity of 35 Ci/mmol were prepared. Reduction of enamide 2 with carrier free tritiu m gas over RhCODCl dimer, (2S, 3S) Chiraphos in methanol gave racemic amide 9c. Hydrolysis followed by resolution of the enantiomers with (R )-methyl benzyl isocyanate gave (R) and (S)-3-aminoquinuclidine-H-3 10 c-S and 10c-R. The enantiopurity purity of both isomers was >99.5%.