MELATONIN INHIBITS MAMMARY-GLAND DEVELOPMENT DURING PREGNANCY

Citation
Ms. Martin et al., MELATONIN INHIBITS MAMMARY-GLAND DEVELOPMENT DURING PREGNANCY, Neuro endocrinology letters, 17(4), 1995, pp. 245-250
Citations number
16
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
ISSN journal
0172780X
Volume
17
Issue
4
Year of publication
1995
Pages
245 - 250
Database
ISI
SICI code
0172-780X(1995)17:4<245:MIMDDP>2.0.ZU;2-A
Abstract
Our objectives were: a) to determine whether melatonin (aMT) could inh ibit physiological mammary gland development during pregnancy and, b) to study the features of aMT binding sites in mammary tissue from preg nant mice. We conclude that: a) aMT (200 mu g/day), administered to mi ce during pregnancy, significantly inhibits the growth of mammary glan ds at the end of this period and, b) that the mammary tissue of pregna nt mice has binding sites for 2-[I-125]-iodomelatonin (affinity, K-d = 1.24 +/- 0.14nM; density, B-max = 40.6 +/- 1.8 fmol/mg protein) which display light/darkness differences with the highest K-d and the lowes t B-max at the end of the period of darkness.