J. Bellone et al., INTERACTION OF HYPOGLYCEMIA WITH PYRIDOSTIGMINE OR ARGININE ON GH SECRETION IN NORMAL SHORT CHILDREN, Neuro endocrinology letters, 17(4), 1995, pp. 259-264
Hypoglycemia, acetylcholine (Ach) and amino acids have stimulatory eff
ect on GH secretion ire humans. To clarify interactions among these st
imuli, we studied in 24 normal short children the effect of insulin-in
duced hypoglycemia (IH) alone and combined with pyridostigmine (PD), a
cholinesterase inhibitor, or arginine (ARG). PD and ARG did not modif
y the GH-releasing effect of IH. Thus, IH, Ach and ARG have similar GH
-releasing effect which is likely mediated by a common mechanism of ac
tion, i.e. inhibition of hypothalamic somatostatin (SS) release.