EFFECTS OF VASOACTIVE-INTESTINAL-PEPTIDE (VIP) AND PEPTIDE HISTIDINE METHIONINE (PHM) ON BASAL AND CORTICOTROPIN-RELEASING HORMONE (CRH)-STIMULATED ACTH CORTISOL SECRETION IN CUSHINGS-DISEASE

Authors
AMBROSI B COLOMBO P RE T PASSINI E BOCHICCHIO D
Citation
B. Ambrosi et al., EFFECTS OF VASOACTIVE-INTESTINAL-PEPTIDE (VIP) AND PEPTIDE HISTIDINE METHIONINE (PHM) ON BASAL AND CORTICOTROPIN-RELEASING HORMONE (CRH)-STIMULATED ACTH CORTISOL SECRETION IN CUSHINGS-DISEASE, Neuro endocrinology letters, 17(4), 1995, pp. 313-318
Citations number
16
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
17
Issue
4
Year of publication
1995
Pages
313 - 318
Database
ISI
SICI code
0172-780X(1995)17:4<313:EOV(AP>2.0.ZU;2-9
Abstract
The possible role of Vasoactive Intestinal Peptide (VIP) and Peptide H istidine Methionine (PHM) as neuromodulators of anterior pituitary fun ction in humans has been suggested. In this work the effects of VIP an d PHM on basal and CRH-stimulated ACTH/F secretion were studied in 7 p atients with Gushing's disease. An ACTH/F response was found in 3 case s during PHM infusion and in 2 of 6 patients during VIP infusion. When compared to CRH alone, a blunted ACTH response to CRH during PHM occu rred in 5 tested patients and during VIP in 3 cases. In conclusion, VI P and PHM are able to rise ACTH/F secretion in some patients with Gush ing's disease, but are unable to potentiate the response to CRH, which rather may be reduced.