SYNTHESIS OF ENANTIOMERICALLY PURE ALPHA-HYDROXYALDEHYDES FROM THE CORRESPONDING ALPHA-HYDROXYCARBOXYLIC ACIDS - NOVEL SUBSTRATES FOR ESCHERICHIA-COLI TRANSKETOLASE

Authors
HUMPHREY AJ TURNER NJ MCCAGUE R TAYLOR SJC
Citation
Aj. Humphrey et al., SYNTHESIS OF ENANTIOMERICALLY PURE ALPHA-HYDROXYALDEHYDES FROM THE CORRESPONDING ALPHA-HYDROXYCARBOXYLIC ACIDS - NOVEL SUBSTRATES FOR ESCHERICHIA-COLI TRANSKETOLASE, Journal of the Chemical Society, Chemical Communications, (24), 1995, pp. 2475-2476
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
24
Year of publication
1995
Pages
2475 - 2476
Database
ISI
SICI code
0022-4936(1995):24<2475:SOEPAF>2.0.ZU;2-6
Abstract
Enantiomerically pure (R)-alpha-hydroxyaldehydes (> 95% eel are prepar ed from the corresponding alpha-hydroxyesters by silyl protection, red uction with diisobutylaluminium hydride, and finally deprotection unde r acidic conditions; subsequent coupling of these aldehydes with lithi um hydroxypyruvate, catalysed by Escherichia coli transketolase, leads to novel optically pure triols.