TOTAL SYNTHESIS OF MILBEMYCIN-G - ASSEMBLY AND COMPLETION OF THE SYNTHESIS

Citation
S. Bailey et al., TOTAL SYNTHESIS OF MILBEMYCIN-G - ASSEMBLY AND COMPLETION OF THE SYNTHESIS, Journal of the Chemical Society, Chemical Communications, (24), 1995, pp. 2521-2522
Citations number
11
Categorie Soggetti
Chemistry
ISSN journal
00224936
Issue
24
Year of publication
1995
Pages
2521 - 2522
Database
ISI
SICI code
0022-4936(1995):24<2521:TSOM-A>2.0.ZU;2-#
Abstract
The Wittig reaction between phosphonium salt 1 and the hydroxybutenoli de 2 followed by deprotection, macrocyclisation, and reduction gives t he 6-hydroxymilbemycin E 9 which by further cyclisation is converted i nto milbemycin G 11.