Kj. Mistry et al., SIGNAL-TRANSDUCTION MECHANISM IN RESPONSE TO AFLATOXIN B-1 EXPOSURE -PHOSPHATIDYLINOSITOL METABOLISM, Chemico-biological interactions, 98(2), 1995, pp. 145-152
A single dose of aflatoxin B-1 (7 mg/kg body weight) to male Wistar ra
ts significantly stimulated the hepatic activity of phosphatidylinosit
ol kinase, a key enzyme in the cell signalling mechanism, 1-7 h follow
ing its administration. Phosphatidylinositol 4-phosphate kinase activi
ty showed only marginal increase, whereas activities of diacylglycerol
kinase and phosphatidylinositol synthetase remained unchanged. The le
vel of diacylglycerol, however, recorded a sharp increase at 1 and 2 h
after carcinogen treatment. The stimulation of phosphatidylinositol c
ycle with faster turnover of active second messengers might be an earl
y step in the manifestation of toxicity and/or carcinogenicity.