To our knowledge none of many past attempts to experimentally modulate
the crossed-uncrossed differential (CUD) or so-called ''interhemisphe
ric transfer time'' derived from appropriate visual reaction time expe
riments has ever succeeded. The present 4 experiments were designed to
establish that (a) under normal attentional constraints, significant
CUDs would be obtained, but that (b) lateral mobilization of attention
by probabilistic (valid and invalid) cuing as to target location woul
d significantly and systematically alter the CUDs. In a baseline exper
iment, a significant CUD was obtained. In Experiments 2-4, CUDs were r
endered nonsignificant by probabilistic cuing. Specific experimental c
onditions generally did not significantly influence the CUD in a syste
matic direction. In only one of many analyses of those results did an
experimental effect on the CUD reach significance: In Experiment 3 int
rasubject mean reaction times yielded a significant complex dissociati
on of CUDs as a function of type of cuing (valid or invalid) and stimu
lus onset asynchrony. It was concluded that the CUD can be significant
ly modulated by target location ruing, but only under very specific co
nditions. The direction of the trends in all the experiments, and in t
he significant finding, suggests that the CUD component that is most m
arkedly influenced by such cues is a postcallosal, motor component.