LOW CEREBROSPINAL-FLUID CONCENTRATIONS OF PEPTIDE HISTIDINE VALINE AND SOMATOSTATIN-28 IN ALZHEIMERS-DISEASE - ALTERED PROCESSING OF PREPROVASOACTIVE INTESTINAL PEPTIDE AND PREPRO-SOMATOSTATIN
M. Yasuda et al., LOW CEREBROSPINAL-FLUID CONCENTRATIONS OF PEPTIDE HISTIDINE VALINE AND SOMATOSTATIN-28 IN ALZHEIMERS-DISEASE - ALTERED PROCESSING OF PREPROVASOACTIVE INTESTINAL PEPTIDE AND PREPRO-SOMATOSTATIN, Neuropeptides, 29(6), 1995, pp. 325-330
Recent studies have indicated that deposition of beta amyloid peptide
in the brains of patients with senile dementia of the Alzheimer type (
SDAT) is a consequence of abnormal processing of the beta amyloid prot
ein precursor. In addition, reduced concentrations of various peptides
have been measured in post-mortem brain tissue and cerebrospinal flui
d (CSF) of patients with SDAT. We determined concentrations of the pep
tides derived from preprovasoactive intestinal peptide (VIP)- peptide
histidine methionine-27 (PHM-27), peptide histidine valine (PHV) and V
IP-and peptides derived from prepro-somatostatin (prepro-SS), SS-14 an
d SS-28, in CSF of patients with SDAT by radioimmunoassay combined wit
h high performance liquid chromatography. We found significantly reduc
ed levels of total PHM-immunoreactivity (IR) and PHV, and unaltered le
vels of PHM-27 and VIP in SDAT, compared with those in controls. Total
SS-IR and SS-28 concentrations were significantly reduced in SDAT, wh
ile SS-14 levels did not differ from those of controls. These results
suggest that an altered processing of the prepro-peptides of VIP and S
S may occur in SDAT and that these alterations might have a significan
t role in the pathogenesis of SDAT.