CHARACTERIZATION OF THE PLASMIDIC BETA-LACTAMASE CMY-2, WHICH IS RESPONSIBLE FOR CEPHAMYCIN RESISTANCE

Authors
BAUERNFEIND A STEMPLINGER I JUNGWIRTH R GIAMARELLOU H
Citation
A. Bauernfeind et al., CHARACTERIZATION OF THE PLASMIDIC BETA-LACTAMASE CMY-2, WHICH IS RESPONSIBLE FOR CEPHAMYCIN RESISTANCE, Antimicrobial agents and chemotherapy, 40(1), 1996, pp. 221-224
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
1
Year of publication
1996
Pages
221 - 224
Database
ISI
SICI code
0066-4804(1996)40:1<221:COTPBC>2.0.ZU;2-1
Abstract
The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cep hamycinase gene (bla(CMY-2)). Its sequence shows one open reading fram e coding for a protein of 381 amino acids. CMY-2 is classified as clas s C beta-lactamase that is closely related to the plasmidic enzymes BI L-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The bl a(CMY-2) gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.