ABSENCE OF EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE ON PHARMACOKINETICS OF ZIDOVUDINE IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS

Authors
CANAS E PACHON J GARCIAPESQUERA F CASTILLO JR VICIANA P CISNEROS JM JIMENEZMEJIAS ME
Citation
E. Canas et al., ABSENCE OF EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE ON PHARMACOKINETICS OF ZIDOVUDINE IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS, Antimicrobial agents and chemotherapy, 40(1), 1996, pp. 230-233
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
1
Year of publication
1996
Pages
230 - 233
Database
ISI
SICI code
0066-4804(1996)40:1<230:AOEOTO>2.0.ZU;2-2
Abstract
Pharmacokinetic parameters of zidovudine (ZDV) were not altered in 16 patients receiving concomitant therapy with ZDV and trimethoprim-sulfa methoxazole by oral administration. ZDV areas under the concentration- time curves were (means +/- standard deviations) 1.80 +/- 0.70 and 1.6 9 +/- 0.64 mu g . h/ml in the absence and presence of trimethoprim-sul famethoxazole, respectively. ZDV clearances were 1.57 +/- 0.61 and 1.7 4 +/- 0.66 liters/h/kg, respectively.