NAPHTHALENE SULFONATE POLYMERS WITH CD4-BLOCKING AND ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVITIES

Authors
RUSCONI S MOONIS M MERRILL DP PALLAI PV NEIDHARDT EA SINGH SK WILLIS KJ OSBURNE MS PROFY AT JENSON JC HIRSCH MS
Citation
S. Rusconi et al., NAPHTHALENE SULFONATE POLYMERS WITH CD4-BLOCKING AND ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVITIES, Antimicrobial agents and chemotherapy, 40(1), 1996, pp. 234-236
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
1
Year of publication
1996
Pages
234 - 236
Database
ISI
SICI code
0066-4804(1996)40:1<234:NSPWCA>2.0.ZU;2-Y
Abstract
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have act ivity against human immunodeficiency virus type 1 in 1-19 cells, perip heral blood mononuclear cells, and primary monocyte/macrophages, are s ynergistic with zidovudine, and do not inhibit tetanus toxoid-stimulat ed T-cell proliferation at anti-human immunodeficiency virus type 1 co ncentrations.