A. Klockgetherradke et al., NAUSEA AND VOMITING AFTER LAPAROSCOPIC SURGERY - A COMPARISON OF PROPOFOL AND THIOPENTONE HALOTHANE ANESTHESIA/, European journal of anaesthesiology, 13(1), 1996, pp. 3-9
Sixty ASA I and II patients scheduled for laparoscopic cholecystectomy
or inguinal herniotomy were randomly assigned to one of two groups: G
roup one (n=30): induction with thiopentone 4-6 mg kg(-1), fentanyl 2
mu g kg(-1), pancuronium 0.03 mg kg(-1), and succinylcholine 1 mg kg(-
1), maintainance with halothane (0.8-1.5%), and N2O in O-2 (Fio(2)=0.3
3). Group two (n=30): induction with propofol 2-3 mg kg(-1), fentanyl
2 mu g kg(-1), pancuronium 0.03 mg kg(-1), and succinylcholine 1 mg kg
(-1), maintainance with propofol 6-10 mg kg(-1) h(-1), and O-2 in N-2
(Fio(2):0.33). Seven of the patients experienced nausea in each group
with group one having higher emetic scores. Six patients in group one
vomited compared to none in group two (P < 0.05). The overall incidenc
e of emetic sequelae (nausea or vomiting) was 43% in group one and 23%
in group two (P=0.17). Patients with propofol anaesthesia had lower e
metic scores and higher recovery scores compared with those after thio
pentone/halothane anaesthesia.