MECHANISMS OF TRANSCRIPTION ACTIVATION BY NUCLEAR RECEPTORS - STUDIESON THE HUMAN GLUCOCORTICOID RECEPTOR TAU(1), TRANSACTIVATION DOMAIN

Authors
MCEWAN IJ DAHLMANWRIGHT K AMLOF T FORD J WRIGHT APH GUSTAFSSON JA
Citation
Ij. Mcewan et al., MECHANISMS OF TRANSCRIPTION ACTIVATION BY NUCLEAR RECEPTORS - STUDIESON THE HUMAN GLUCOCORTICOID RECEPTOR TAU(1), TRANSACTIVATION DOMAIN, Mutation research, 333(1-2), 1995, pp. 15-22
Citations number
43
Categorie Soggetti
Genetics & Heredity",Biology,"Biothechnology & Applied Migrobiology
Journal title
Mutation research → ACNP
ISSN journal
00275107
Volume
333
Issue
1-2
Year of publication
1995
Pages
15 - 22
Database
ISI
SICI code
0027-5107(1995)333:1-2<15:MOTABN>2.0.ZU;2-Q
Abstract
Nuclear receptors are important signalling molecules that directly med iate the effects of hormones, vitamins and xenobiotic compounds at the level of gene expression. Several members of this superfamily of prot eins have been implicated in receptor-dependent carcinogenesis. In thi s review, we summarise how these receptors can function as transcripti on factors with particular emphasis on the mechanism of transcription activation by the human glucocorticoid receptor tau(1) transactivation domain.