SINGLE-DOSE OF NANDROLONE DOES NOT PREVENT POSTOPERATIVE FIBRINOLYTICSHUTDOWN

Nandrolone 50 mg, 100 mg, or placebo was intramuscularly injected prio r to surgery into patients admitted for gynecological operations. Plas minogen and fibrinogen concentration, plasminogen activator inhibitor (PAI) activity and fibrinolytic activity in euglobulins were determine d until the seventh postoperative day. Injection of nandrolone resulte d in a delay in the postoperative rise of fibrinogen, but an earlier i ncrease of plasminogen after surgery, as compared with the control gro up, 50 mg of this anabolic steroid given before surgery prevented the postoperative increase of PAI activity observed in the placebo group, while a 100 mg dose caused a temporary decline of this activity until the third postoperative day. The fibrinolytic activity in euglobulins was significantly decreased on the first postoperative day in the pati ents of all groups and no differences were found among the groups up t o the end of determinations. It is concluded that the injection of nan drolone prior to surgery temporarily inhibits the postoperative rise i n PAI activity but does not prevent fibrinolytic shutdown occurring af ter surgery.