Internal carotid artery (ICA) hypoplasia is a rare congenital anomaly
that is sometimes difficult to distinguish from acquired diseases asso
ciated with narrowing of the ICA. As the carotid canal develops in ass
ociation with the ICA, a hypoplastic carotid artery should result in a
hypoplastic carotid canal. We used skull base CT scans to measure the
size of carotid canals in 4 patients with ICA hypoplasia (bilateral i
n 1) and in 30 consecutive controls. The diameter of the carotid canal
was significantly smaller in the patients with carotid hypoplasia (2.
4-3.0 mm, on the involved side) than in the controls (mean = 6.4 +/- 0
.8 mm, range = 5.2-9.8 mm) with no overlapping value (p < 0.001). The
ratio of the largest to the smallest carotid diameter was greater than
2 in patients with unilateral hypoplasia, while it never exceeded 1.2
in controls. CT scan of the skull base is a simple and reliable tool
for confirming the diagnosis of ICA hypoplasia.