LOW-DENSITY-LIPOPROTEIN PARTICLE-SIZE DISTRIBUTION IN END-STAGE RENAL-DISEASE TREATED WITH HEMODIALYSIS OR PERITONEAL-DIALYSIS

Dyslipidemia accompanies end-stage renal disease (ESRD) and contribute s to the high incidence of cardiovascular disease in patients on chron ic dialysis treatment The lipid abnormalities of elevated triglyceride level and reduced high-density lipoprotein cholesterol level that occ ur in ESRD are associated in the normal population with an altered dis tribution of low-density lipoprotein (LDt) particle size, a pattern as sociated with increased risk of coronary heart disease, To assess the effect of ESRD on LDL particle size distribution, we examined plasma l ipid levels and LDL particle size in 43 subjects on chronic hemodialys is, 23 subjects on continuous ambulatory peritoneal dialysis, and 30 c ontrol subjects with normal renal function, Of subjects on continuous ambulatory peritoneal dialysis, 48% had small LDL particle size compar ed with 23% of subjects on hemodialysis and 7% of control subjects, Su bjects on both forms of dialysis also had higher triglyceride levels a nd lower high-density lipoprotein cholesterol levels that correlated w ith LDL particle size, We conclude that altered LDL particle size form s an important component of the metabolic abnormalities that contribut e to the increased cardiovascular risk found in ESRD. (C) 1996 by the National Kidney Foundation, Inc.