CHROMOSOMAL LOCALIZATION OF THE MOUSE SRC-LIKE ADAPTER PROTEIN (SLAP)GENE AND ITS PUTATIVE HUMAN HOMOLOG SLA

Molecules containing Src-homology 2 (SH2) and Src-homology 3 (SH3) dom ains are critical components of signal transduction pathways that serv e to relay signals originating from the cell surface to the interior o f the cell, Src-like adapter protein (SLAP) is a recently described ad apter protein that binds activated the Eck receptor protein-tyrosine k inase, Although SLAP bears a striking homology to the SH3 and SH2 doma ins of the Src family of nonreceptor tyrosine kinases, it does not con tain a tyrosine kinase catalytic domain, In this report, the Slap gene was mapped by linkage analysis to mouse chromosome 15, while its puta tive human homolog (SLA) was identified and mapped to human 8q22.3-qte r using a panel of somatic cell hybrids. (C) 1995 Academic Press, Inc.