Laser-assisted uvulopalatoplasty (LAUP) can reduce snoring by sequenti
ally removing excessive vibratory tissue of the velopharynx. The proce
dure can be performed under local anesthesia in an office setting, Sin
ce the appearance of the soft palate is similar after both LAUP and uv
ulopalatopharyngoplasty, LAUP may also be efficacious in the managemen
t of obstructive sleep apnea syndrome (OSAS). LAUP was performed in 34
consecutive prospectively evaluated patients with OSAS, Of the 34 pat
ients, 28 (82%) were male; the mean age was 53 years, and the mean bod
y mass index was 31.1. In the study population of 13 patients who comp
leted preoperative and postoperative sleep studies, the apnea index de
creased from 19.4 to 4.2 (P=.006), the respiratory disturbance index (
RDI) decreased from 31.2 to 15.7 (P=.092), and mean lowest oxyhemoglob
in saturation increased from 82.3% to 85.0% (P=.581). The RDI fell to
10 or lower in 38.5.% of patients and was reduced by at least 50% in 5
3.8% of the study group. Snoring was significantly reduced in 92.3% of
patients (P<.001). These early results suggest that LAUP may be effic
acious in the management of OSAS.