OUTCOME OF PYRIFORM SINUS CANCER - A RETROSPECTIVE INSTITUTIONAL REVIEW

Pyriform sinus cancer remains one of the most lethal of human diseases . Regardless of approach attempted significant enhancement of survival has not been realized, In this study a retrospective single instituti onal review of all patients diagnosed with pyriform sinus cancer durin g the 1980s was conducted, The results in 93 patients show an overall determinant B-year survival of 14.3%, Of patients undergoing surgery, median determinant survival was 37 months and B-year survival was 34.6 %. In resectable patients treated with radiation with or without chemo therapy, median determinant survival was 13 months with B-year surviva l of 7.1% (P<.01). Surgical salvage was attempted in 8 patients withou t success. In conclusion, due to the apparent survival advantage for s urgical patients, the low rate of surgical salvage, and the relatively low rate of organ preservation in prospective trials, pyriform sinus cancer is a poor site for organ preservation. Surgery followed by radi ation therapy should remain the standard of care for pyriform sinus ca ncer.