AZT MODULATION OF TRIMETREXATE MYELOTOXICITY - EVIDENCE FROM AN HL-60MODEL

Authors
NUSBAUM NJ ABRAHAM T
Citation
Nj. Nusbaum et T. Abraham, AZT MODULATION OF TRIMETREXATE MYELOTOXICITY - EVIDENCE FROM AN HL-60MODEL, Research communications in molecular pathology and pharmacology, 90(3), 1995, pp. 403-412
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
90
Issue
3
Year of publication
1995
Pages
403 - 412
Database
ISI
SICI code
1078-0297(1995)90:3<403:AMOTM->2.0.ZU;2-Z
Abstract
AZT is widely used in combination with other potentially myelotoxic dr ugs. Bone marrow suppression may limit the vigor of therapy directed a t HIV itself, opportunistic infections, and/or AIDS-associated maligna ncies. Evidence from an HL60 model suggests that toxicity is of most c oncern with simultaneous use of multiple agents, and that staggered us e of different agents may in some cases be a more effective strategy.