COMPLEX IGA GAMMOPATHY IN GAUCHERS-DISEASE

A 55-year-old Jewish patient was simultaneously diagnosed as having Ga ucher's disease and IgA multiple myeloma. Serum protein electrophoresi s and immunoelectrophoresis showed two different IgA kappa type monocl onal spikes. After four years of observation, a rapid fatal course of disease developed together with expression of J chain protein and an a dditional IgA lambda paraprotein. Although dysproteinaemias and multip le myeloma have occasionally been reported in Gaucher's patients, such a complex gammopathy has to the best of our knowledge not yet been de scribed.