BONE AND BRAIN INVOLVEMENT IN A CASE OF DIFFUSE LARGE B-CELL LYMPHOMAASSOCIATED WITH T(2-3)(P12-Q27)

We report a 57-year-old male with non-Hodgkin's lymphoma (NHL) associa ted with t(2;3)(p12;q27). The patient showed bone lesions at presentat ion and brain involvement at relapse in addition to systemic lymph nod e swelling. Histological diagnosis was malignant lymphoma, diffuse, la rge cell, immunoblastic, plasmacytoid, Chromosome analysis revealed t( 2;3) which is a variant type of t(3;14)(q27;q32). Fluorescence in situ hybridization (FISH) analysis disclosed splits of signals of BCL-6 ge ne, Among the cases reported in the literature, the common feature of t(2;3)(p11 or p12;q27) was diffuse, large cell lymphoma of B cell, kap pa phenotype and four patients immunosuppressive state before lymphoma .