DEPENDENCE OF NITROGEN-REGULATION AND PHOSPHORUS-REGULATION OF BETA-LACTAM ANTIBIOTIC PRODUCTION BY STREPTOMYCES-CLAVULIGERUS ON AERATION LEVEL

Authors
FANG A DEMAIN AL
Citation
A. Fang et Al. Demain, DEPENDENCE OF NITROGEN-REGULATION AND PHOSPHORUS-REGULATION OF BETA-LACTAM ANTIBIOTIC PRODUCTION BY STREPTOMYCES-CLAVULIGERUS ON AERATION LEVEL, Journal of industrial microbiology, 15(5), 1995, pp. 407-410
Citations number
11
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Journal of industrial microbiology → ACNP
ISSN journal
01694146
Volume
15
Issue
5
Year of publication
1995
Pages
407 - 410
Database
ISI
SICI code
0169-4146(1995)15:5<407:DONAPO>2.0.ZU;2-K
Abstract
Interference with beta-lactam production in Streptomyces clavuligerus by ammonium and phosphate ions, normally observed with optimum levels of aeration, was eliminated by restriction of the air supply, Under su ch a restriction, ammonium slightly stimulated and phosphate markedly stimulated beta-lactam antibiotic production. These are rare examples of 'regulation reversal' by an environmental modification.