A. Fang et Al. Demain, DEPENDENCE OF NITROGEN-REGULATION AND PHOSPHORUS-REGULATION OF BETA-LACTAM ANTIBIOTIC PRODUCTION BY STREPTOMYCES-CLAVULIGERUS ON AERATION LEVEL, Journal of industrial microbiology, 15(5), 1995, pp. 407-410
Interference with beta-lactam production in Streptomyces clavuligerus
by ammonium and phosphate ions, normally observed with optimum levels
of aeration, was eliminated by restriction of the air supply, Under su
ch a restriction, ammonium slightly stimulated and phosphate markedly
stimulated beta-lactam antibiotic production. These are rare examples
of 'regulation reversal' by an environmental modification.