Ss. Katyare et Rr. Rajan, EFFECT OF LONG-TERM IN-VIVO TREATMENT WITH IMIPRAMINE ON THE OXIDATIVE ENERGY-METABOLISM IN RAT-BRAIN MITOCHONDRIA, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 112(3), 1995, pp. 353-357
The effects of long-term administration of the tricyclic antidepressan
t imipramine on energy metabolism of rat brain mitochondria were exami
ned, Intraperitoneal administration of the drug resulted in significan
t stimulation of the state 3 respiration rates with glutamate, pyruvat
e + malate, beta-hydroxybutyrate and succinate as the substrates. The
effect was evident within a week of imipramine administration and was
sustained through the second week of the drug treatment. State 4 respi
ration rates were also found to be increased in general, However, the
respiration with ascorbate + TMPD as the electron donor system decreas
ed, The intramitochondrial content of cytochrome b and c + c(1) increa
sed in the first week of the drug treatment; that of aa, cytochrome in
creased only in the second week.