PERSISTENCE - A NEW STATISTIC FOR CHARACTERIZING ION-CHANNEL ACTIVITY

Authors
FREDKIN DR RICE JA COLQUHOUN D GIBB AJ
Citation
Dr. Fredkin et al., PERSISTENCE - A NEW STATISTIC FOR CHARACTERIZING ION-CHANNEL ACTIVITY, Philosophical transactions-Royal Society of London. Biological sciences, 350(1334), 1995, pp. 353-367
Citations number
7
Categorie Soggetti
Biology
Journal title
Philosophical transactions-Royal Society of London. Biological sciences → ACNP
ISSN journal
09628436
Volume
350
Issue
1334
Year of publication
1995
Pages
353 - 367
Database
ISI
SICI code
0962-8436(1995)350:1334<353:P-ANSF>2.0.ZU;2-Y
Abstract
We introduce and illustrate by examples a new statistical technique, t he persistence function, for characterizing ion-channel activity in a single-channel patch-clamp recording. Persistence is a function of bot h current and time. It is the probability that the current is at a giv en level (conditional on it having been at that level at an earlier ti me). Viewed as a function of current it exhibits the prominent conduct ance levels present in the recording, and viewed as a function of time for a conductance level it portrays the kinetics at that level.