ACQUIRED FACTOR-VIII INHIBITOR HEMOPHILIA IN ADVANCED CERVICAL-CARCINOMA

Acquired inhibitors of factor VIII are rarely observed as a life threa tening complication of advanced neoplastic diseases. Profuse bleeding and isolated PTT-prolongation raise the suspicion for this coagulopath y. In this Case Report the authors describe the appearance of a plasma tic circulating antibody against factor VIII in advanced cervical carc inoma. Local therapeutic measures to arrest the bleeding or high-dose factor substitution did not influence the clinical outcome of the pati ent substantially. In our experience only the combination of immunsupp ressive treatment (cyclophophamide/prednisolone) with FEIBA and AT III has proved to be effective for cessation of the clinical symptoms and sufficient suppression of serum levels of the inhibitor.