ACQUIRED FACTOR-VIII INHIBITOR HEMOPHILIA IN ADVANCED CERVICAL-CARCINOMA

Citation
R. Heyd et al., ACQUIRED FACTOR-VIII INHIBITOR HEMOPHILIA IN ADVANCED CERVICAL-CARCINOMA, Tumordiagnostik & Therapie, 16(6), 1995, pp. 242-245
Citations number
21
Categorie Soggetti
Oncology
Journal title
ISSN journal
0722219X
Volume
16
Issue
6
Year of publication
1995
Pages
242 - 245
Database
ISI
SICI code
0722-219X(1995)16:6<242:AFIHIA>2.0.ZU;2-A
Abstract
Acquired inhibitors of factor VIII are rarely observed as a life threa tening complication of advanced neoplastic diseases. Profuse bleeding and isolated PTT-prolongation raise the suspicion for this coagulopath y. In this Case Report the authors describe the appearance of a plasma tic circulating antibody against factor VIII in advanced cervical carc inoma. Local therapeutic measures to arrest the bleeding or high-dose factor substitution did not influence the clinical outcome of the pati ent substantially. In our experience only the combination of immunsupp ressive treatment (cyclophophamide/prednisolone) with FEIBA and AT III has proved to be effective for cessation of the clinical symptoms and sufficient suppression of serum levels of the inhibitor.