MINIMUM INHIBITORY CONCENTRATIONS OF INTESTINAL ESCHERICHIA-COLI FROMBROILER-CHICKENS AFTER ORAL-ADMINISTRATION OF APRAMYCIN

Citation
A. Kobe et al., MINIMUM INHIBITORY CONCENTRATIONS OF INTESTINAL ESCHERICHIA-COLI FROMBROILER-CHICKENS AFTER ORAL-ADMINISTRATION OF APRAMYCIN, Journal of Applied Bacteriology, 80(1), 1996, pp. 26-30
Citations number
13
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
ISSN journal
00218847
Volume
80
Issue
1
Year of publication
1996
Pages
26 - 30
Database
ISI
SICI code
0021-8847(1996)80:1<26:MICOIE>2.0.ZU;2-7
Abstract
This study describes the influence of apramycin on minimum inhibitory concentrations (MIG) of intestinal Escherichia coli in young broiler c hickens, after oral administration of the antibiotic at a dosage equiv alent to a prophylactic course of treatment for 10 d. The bacteria wer e isolated from cloacal swabs and caecal contents. MICs were determine d by agar dilution procedures. MIC of npl am! cin for the investigated strains ranged from 1 mu g ml(-1) to 16 mu g ml(-1). Strains obtained from undosed birds mainly had MIC values of 2 mu g ml(-1). MIC values of 8 mu g ml(-1) or more were recorded only among isolates obtained f rom chickens which had received apramycin. Administration of apramycin resulted in a slight but statistically significant increase in the av erage MIG. Statistically higher average MICs were recorded among isola tes from cloacal swabs 10 d after withdrawal until the end of the expe riment. For strains from caecal contents, this was demonstrated only o n one sampling occasion, 15 d after withdrawal.