SYSTEMATIC SEARCH OF SUSCEPTIBILITY LOCI WITH METHODS USING GAMETIC DISEQUILIBRIUM

Authors
BICKEBOLLER H MARGARITTEJEANNIN P BABRON MC CLERGETDARPOUX F
Citation
H. Bickeboller et al., SYSTEMATIC SEARCH OF SUSCEPTIBILITY LOCI WITH METHODS USING GAMETIC DISEQUILIBRIUM, Genetic epidemiology, 12(6), 1995, pp. 577-582
Citations number
8
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
12
Issue
6
Year of publication
1995
Pages
577 - 582
Database
ISI
SICI code
0741-0395(1995)12:6<577:SSOSLW>2.0.ZU;2-D
Abstract
Susceptibility genes are identified for a simulated complex trait by a systematic genome search for linkage between disease and a genetic ma rker in the presence of gametic disequilibrium. The transmission/diseq uilibrium tests TDT, or TDT, for multiallelic markers compare transmit ted and nontransmitted alleles or the genotypes formed by the two tran smitted alleles and the genotypes formed by the two nontransmitted all eles, respectively. With these two tests we were able to identify the two markers D1G31 and D5G23. Under the simulating model these are in f act two susceptibility genes involved in the disease. (C) 1995 Wiley-L iss, Inc.