LOGISTIC TRANSMISSION MODELING OF SIMULATED DATA

A nonparametric method for linkage analysis has been developed and app lied to the Problem 1 data set of the Genetic Analysis Workshop 9. Bas ically, the univariate matched pair strategy of the transmission diseq uilibrium test has been adapted to multivariate modeling using the con ditional logistic function. After setting the critical value for signi ficance at p less than or equal to 0.0001, models at only D5G23 and D1 G31 appear to be significant (p < 10(-7)). Logistic transmission model ing is a powerful method for establishing linkage by disequilibrium. ( C) 1995 Wiley-Liss, Inc.