SCREENING FOR LINKAGE AND ASSOCIATION IN NUCLEAR FAMILIES

Authors
KNAPP M DURNER M BAUR MP
Citation
M. Knapp et al., SCREENING FOR LINKAGE AND ASSOCIATION IN NUCLEAR FAMILIES, Genetic epidemiology, 12(6), 1995, pp. 619-623
Citations number
5
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
12
Issue
6
Year of publication
1995
Pages
619 - 623
Database
ISI
SICI code
0741-0395(1995)12:6<619:SFLAAI>2.0.ZU;2-T
Abstract
We applied linkage analysis with a sib-pair method, which also takes i nto account information on unaffected siblings, and family-based metho ds of association analysis to determine the disease affecting loci in Problem 1. Whereas the first two disease loci were correctly identifie d by association analysis, the sib-pair linkage method failed to detec t the disease loci 3 and 4. We therefore determined the data structure and sample size necessary for demonstrating linkage to these loci. (C ) 1995 Wiley-Liss, Inc.