SIB-BASED DETECTION OF QTLS

Association and transmission/nontransmission analyses were used in a s plit sample design to identify disease susceptibility alleles at two l oci. Sib-pair analysis on various subsets of the data identified an ad ditional four regions that yielded signals of disease predisposing qua ntitative trait loci (QTLs). Three of these four regions represented T ype I errors. A new simulation indicates that a multiplex sampling str ategy would substantially improve QTL detection for this oligogenic tr ansmission model. (C) 1995 Wiley-Liss, Inc.