SIMULATION OF A COMMON OLIGOGENIC DISEASE WITH QUANTITATIVE RISK-FACTORS - GAW9 PROBLEM 2 - THE ANSWERS

For Problem 2, simulated family data were provided for a common oligog enic disease that was defined by imposing a threshold, T, on a quantit ative trait, Q1. Every individual with a value of Q1 > T (where T = 87 .5) was defined as affected. Participants were told that three other q uantitative traits (Q2, Q3, and Q4) and an environmental factor (EF) a lso were thought to be associated with the disease as intervening vari ables, and that 12 candidate loci (C1 - C12) were postulated to influe nce traits associated with the disease. The tasks for GAW9 were to cha racterize the genetic and environmental contribution to Q1 (and the di sease), Q2, Q3, and Q4, and to localize any single genes that had dete ctable effects. (C) 1995 Wiley-Liss, Inc.