A BRUTE FORCE DICHOTOMIZATION APPROACH TO QUANTITATIVE TRAIT LINKAGE ANALYSIS

Authors
BAILEY JN ALMASY L
Citation
Jn. Bailey et L. Almasy, A BRUTE FORCE DICHOTOMIZATION APPROACH TO QUANTITATIVE TRAIT LINKAGE ANALYSIS, Genetic epidemiology, 12(6), 1995, pp. 719-722
Citations number
3
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
12
Issue
6
Year of publication
1995
Pages
719 - 722
Database
ISI
SICI code
0741-0395(1995)12:6<719:ABFDAT>2.0.ZU;2-M
Abstract
The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichoto mization does not in itself preclude the detection of loci which accou nt for as little as 16% of the genetic variance of the disease. The ef fects of inclusion of known covariates and quantitative trait linkage analysis are also discussed. (C) 1995 Wiley-Liss, Inc.