2-LOCUS APPROACH OF SEGREGATION AND LINKAGE ANALYSIS IN THE STUDY OF COMPLEX TRAITS

A two-locus segregation and linkage-analysis approach was used to char acterize the genetic control of a complex trait (Q1) and to localize t he genes that have detectable effects. The results suggested that a tw o-locus Mendelian model fit the data significantly better than a one-l ocus model. The linkage results based on the most parsimonious two-loc us model revealed linkage of Q1 to two areas (MG2 and MG3), while ther e was less evidence for linkage using one-locus models. Results also s uggested that the subphenotypes (Q2 and Q3) provided useful informatio n for further analysis of Q1 using two-locus models. (C) 1995 Wiley-Li ss, Inc.