U. Knees et al., LLIACA VEIN-THROMBOSIS ASSOCIATED WITH PR OTEIN-C DEFICIENCY AFTER INFECTIOUS-MONONUCLEOSIS, Monatsschrift fur Kinderheilkunde, 141(12), 1993, pp. 928-931
Subsequent to an infectious mononucleosis a 15 year old girl developed
a thrombosis of the iliaca vein. Laboratory evaluation revealed a het
erozygous form of protein C deficiency. An infusion with r-tPA (= reco
mbinant tissue plasminogen activator) at a rate of 0.02 mg/kg BW/h ove
r 96 hours failed to reopen the vessel. After intermittent heparin the
rapy longterm treatment with coumarin began. Three months later the il
iaca vein was partially re canalised.