S. Sudo et al., A CASE OF OVARIAN-CARCINOMA WITH PRODUCTION OF GRANULOCYTE-COLONY-STIMULATING FACTOR, British Journal of Haematology, 92(1), 1996, pp. 137-139
A 60-year female with ovarian carcinoma showed marked leucocytosis. Af
ter exploratory laparotomy she had received carboplatin-based chemothe
rapy, but she died of respiratory failure. In this case the immunohist
ochemical examination of the tumor cells showed partial-positive stain
ing for anti-G-CSF monoclonal antibody in addition to the elevation of
the serum G-CSF concentration. This case is the first report of an ov
arian carcinoma producing G-CSF.