Considerable research over the past few decades on the nature and trea
tment of schizophrenia has yielded important advances to improve the o
utcomes of this disorder. Recent action plans, including the ''Decade
of the Brain,'' the National Institute of Mental Health (NIMH) A Natio
nal Plan for Schizophrenia Research, and NIMH's report, Caring for Peo
ple With Severe Mental Disorders: A National Plan of Research to Impro
ve Services, promise major new advances over the next several years. A
s research advances, it is critical to ensure that patients in everyda
y practice receive the most effective treatments being developed. This
issue of the Schizophrenia Bulletin reviews the research, on outcomes
of treatments for schizophrenia and lays out an agenda for available
research knowledge to be translated into practice and for future resea
rch to improve outcomes.