Lp. Liu et Wa. Donaldson, SYNTHESIS OF THE C1-C8 TETRAHYDROPYRANYL SEGMENT OF THE ANTIFUNGAL AGENT AMBRUTICIN AND ITS C3 EPIMER, Synlett, (1), 1996, pp. 103-104
The synthesis of the C1-C8 segment (2) of ambruticin and its C3 epimer
(9), were accomplished starting from the diethyldithioacetal of L-ara
binose in 10 and 8 steps (10% and 16% yield) respectively.