PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES .40. SYNTHESIS OF 1,4-DIHYDROPYRIDO[2,3-B]INDOLIZIN-4-ONE DERIVATIVES

Authors
KAKEHI A ITO S HAYASHI S FUJII T
Citation
A. Kakehi et al., PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES .40. SYNTHESIS OF 1,4-DIHYDROPYRIDO[2,3-B]INDOLIZIN-4-ONE DERIVATIVES, Bulletin of the Chemical Society of Japan, 68(12), 1995, pp. 3573-3580
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
68
Issue
12
Year of publication
1995
Pages
3573 - 3580
Database
ISI
SICI code
0009-2673(1995)68:12<3573:PONNH.>2.0.ZU;2-7
Abstract
The title compounds, 1,4-dihydropyrido[2,3-b]indolizin-4-one derivativ es, were prepared in moderate to good yields via the N-formylation of some 3-acetyl-2-(alkylamino)indolizines with triethyl orthoformate and acetic anhydride in the presence of zinc chloride followed by the int ramolecular dehydration of the resulting 3-acetyl-2-(N-alkylformamido) indolizines under strong alkaline conditions.