CONTROLLED CROSS CIRCULATION IN DOGS - EFFECTS ON DONOR HEMODYNAMICS

Controlled cross circulation (CCC) was performed in six pairs of dogs for 45 minutes with aortic cross clamping and cardioplegia. Data were collected in donor dogs at 10 minute intervals three times before, thr ee times during, and three times after CCC and included arterial blood pressure, pulmonary capillary wedge pressure (PCWP), central venous p ressure (CVP), cardiac index (CI), heart rate (HR), blood gas analysis , temperature, maximum rate of rise of left ventricular pressure dP/dt max/End diastolic volume (EDV), blood volume (BV), complete blood cou nt (CBC) and activated clotting times (ACT). Pulse pressure (PP), syst emic vascular resistance (SVR), oxygen delivery (Dot), and left ventri cular cardiac work (LVCW) were calculated. Arterial blood pressure, CV P, blood gas analysis, temperature, BV, CBC, and ACT were measured in recipient dogs. During CCC, donor hemodynamic changes resembled those observed in models of acute onset arteriovenous fistulas. Insidious BV shifts can occur despite the use of occlusive roller pumps. After CCC , donor hemodynamics resembled acute blood loss, characterized by decr eases in mean arterial pressure (MAP), CVP, PCWP, and CI, and increase s in SVR and dP/dt max/EDV. These changes were probably caused by pump imbalance and BV shift to the recipient dog. (C) 1996 by The American College of Veterinary Surgeons.