ANALOGS OF THE BETA-TURN OF THE CYCLODEPSIPEPTIDE DIDEMNIN-B

Authors
RAMANJULU JM JOULLIE MM
Citation
Jm. Ramanjulu et Mm. Joullie, ANALOGS OF THE BETA-TURN OF THE CYCLODEPSIPEPTIDE DIDEMNIN-B, Tetrahedron letters, 37(3), 1996, pp. 311-314
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
3
Year of publication
1996
Pages
311 - 314
Database
ISI
SICI code
0040-4039(1996)37:3<311:AOTBOT>2.0.ZU;2-S
Abstract
Three side chain analogs of didemnin B were synthesized. All three ana logs of the only conventional type II beta-turn present in didemnin B differed in the functionality incorporated in the threonine residue. T he cytotoxic activities of these analogs were evaluated and one of the m exhibited weak activity.