A CONVENIENT SYNTHESIS OF OPTICALLY-ACTIVE PHENYLGLYCINE

Authors
CALMES M DAUNIS J MAI N NATT F
Citation
M. Calmes et al., A CONVENIENT SYNTHESIS OF OPTICALLY-ACTIVE PHENYLGLYCINE, Tetrahedron letters, 37(3), 1996, pp. 379-380
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
3
Year of publication
1996
Pages
379 - 380
Database
ISI
SICI code
0040-4039(1996)37:3<379:ACSOOP>2.0.ZU;2-C
Abstract
Optically active R phenylglycine methyl ester hydrochloride (ee = 98%) was prepared in 90% yield from racemic phenylglycine. The key step wa s the base catalysed diastereoselective addition at -78 degrees C of R pantolactone to the N-phthalyl protected phenylglycine ketene