THERAPY OF TRAVELERS DIARRHEA

Authors
Citation
R. Bruns et R. Raedsch, THERAPY OF TRAVELERS DIARRHEA, Die medizinische Welt, 46(12), 1995, pp. 591-596
Citations number
39
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
00258512
Volume
46
Issue
12
Year of publication
1995
Pages
591 - 596
Database
ISI
SICI code
0025-8512(1995)46:12<591:TOTD>2.0.ZU;2-A
Abstract
Depending on the destination of the voyage the risk of travelers' diar rhea (TD) can exceed 50%. The therapeutic efficacy of the fixed combin ation of ethacridine-lactate and tannalbuminate (ET) has been investig ated vs. Saccharomyces cerevisiae Hansen CBS 5926 [SC] in a randomized parallel group comparison study in 60 tourists with TD in Tunisia. Th e study duration was 5 days. Dose regimen: either two Tannacomp(TM) fi lm-coated tablets with 50 mg ethacridine-lactate and 500 mg tannalbumi nate three times daily or three Perenlerol(TM) capsules with 50 mg SC four times daily. 43 patients completed the study. Mean age: 33.7 year s (ET), 31.0 years (SC). The duration of diarrhea (DD) has been define d as the primary variable for confirmative statistical analysis. As se condary variables have been defined stool frequency and consistency, a bdominal cramps, nausea, vomiting, global assessment of therapy, toler ance and adverse drug reactions. Both ET and SC showed strong antidiar rheal effectiveness. In 2/3 of the ET group the DD was shortened to on e day, in 1/3 to two days (mean 1.4 days, = 33.8 h). In the SC group t he DD was shortened to 2.1 days (= 51.4 h) (mean). ET has been signifi cantly superior over SC (p = 0.0394). The relief from abdominal cramps and vomiting has been better under ET. There were no adverse drug rea ctions in both groups.