LONG-TERM NIFEDIPINE TREATMENT REDUCES CALCIUM OVERLOAD IN ISOLATED REPERFUSED HEARTS OF DIABETIC RATS

Authors
HIGA S SHIMABUKURO M SHINZATO T NAGAMINE F MURAKAMI K TAKASU N
Citation
S. Higa et al., LONG-TERM NIFEDIPINE TREATMENT REDUCES CALCIUM OVERLOAD IN ISOLATED REPERFUSED HEARTS OF DIABETIC RATS, General pharmacology, 26(8), 1995, pp. 1679-1686
Citations number
42
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
26
Issue
8
Year of publication
1995
Pages
1679 - 1686
Database
ISI
SICI code
0306-3623(1995)26:8<1679:LNTRCO>2.0.ZU;2-I
Abstract
1. Streptozotocin-induced diabetic rats showed poor post-ischemic reco very in isolated working rat hearts. 2. Diabetic rats showed myocardia l Na+ accumulation after ischemia, and Ca2+ level and water content el evation after reperfusion. 3. A 6-wk nifedipine treatment improved pos t-ischemic recovery of cardiac parameters and prevented myocardial Na accumulation after ischemia and myocardial Ca2+ level and water conte nt elevation after reperfusion of diabetic rats. 4. Results suggest th at nifedipine treatment improves cardiac dysfunction in the reperfused ischemic hearts of diabetic rats through normalization of the Na+-Ca2 + imbalance and water content.