1,25-DIHYDROXYVITAMIN D-MEDIATED HYPERCALCEMIA IN A RENAL-TRANSPLANT RECIPIENT

Hypercalcemia occurs in 10 to 30% of renal transplant recipients and i s most often due to persistent hyperparathyroidism. Herein we describe a patient with a history of hyperparathyroidism who sought medical as sessment because of recurrence of hypercalcemia 7 Sears after a succes sful renal transplantation, The hypercalcemia was associated with a no rmal serum phosphate level, a low to normal parathyroid hormone level, virtually undetectable levels of parathyroid hormone-related protein, and increased 1,25-dihydroxyvitamin D levels, Further assessment led to the diagnosis of an underlying lymphoma, To our knowledge, this is the first report of 1,25-dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient with lymphoma, The possibility of an unde rlying lymphoproliferative disorder should be considered in the differ ential diagnosis of hypercalcemia in a renal transplant recipient.