MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II I-E-INDEPENDENT TRANSMISSION OF C3H MOUSE MAMMARY-TUMOR VIRUS

Authors
WRONA T DUDLEY JP
Citation
T. Wrona et Jp. Dudley, MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II I-E-INDEPENDENT TRANSMISSION OF C3H MOUSE MAMMARY-TUMOR VIRUS, Journal of virology, 70(2), 1996, pp. 1246-1249
Citations number
18
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
70
Issue
2
Year of publication
1996
Pages
1246 - 1249
Database
ISI
SICI code
0022-538X(1996)70:2<1246:MHCCIT>2.0.ZU;2-Y
Abstract
C57/BL/6 mice are resistant to C3H mouse mammary tumor virus (MMTV)-in duced mammary tumorigenesis and lack major histocompatibility complex class II I-E molecules that are essential for presentation of C3H supe rantigen to T cells. T cells are needed for transmission of milk-borne MMTV from the gut to the mammary gland. In this report, we show that infectious C3H MMTV is produced by C57BL/6 mice that nurse on C3H moth ers but that virus production in the mammary gland is delayed compared with that in I-E(+) mouse strains.