Tracheal obstruction and superior vena cava (SVC) syndrome are rare co
mplications of retrosternal goiter. These two conditions present a dif
ficult diagnostic and therapeutic challenge. Malignancy is the most co
mmon cause of SVC syndrome. Determining whether SVC syndrome is due to
a benign or malignant process is imperative before instituting treatm
ent, but this determination may be difficult. We present a case of a p
atient presenting with upper airway obstruction and SVC syndrome with
a large mediastinal mass. The mass was determined to be a multinodular
goiter. The patient was managed by surgical removal of the goiter wit
h complete resolution of symptoms. This case illustrates the need for
careful preoperative evaluation and the importance of establishing a h
istologic diagnosis prior to initiating treatment for SVC syndrome. (C
) 1994 John Wiley & Sons, Inc.