P. Genin et al., A NOVEL PRD-I AND TG BINDING-ACTIVITY INVOLVED IN VIRUS-INDUCED TRANSCRIPTION OF IFN-A GENES, Nucleic acids research, 23(24), 1995, pp. 5055-5063
Comparative analysis of the inducible elements of the mouse interferon
A4 and A11 gene promoters (IE-A4 and IE-A11) by transient transfectio
n experiments, DNase I footprinting and electrophoretic mobility shift
assays resulted in identification of a virus-induced binding activity
suggested to be involved in NBV-induced activation of transcription o
f these genes, The virus-induced factor, termed VIF, is activated earl
y by contact of virions with cells, It specifically recognizes the PRD
I-like domain shared by both inducible elements, as well as the TO-li
ke domain of IE-A4, This factor, distinct from the IRF-1, IRF-2 and th
e alpha F1 binding proteins and presenting a different affinity patter
n from that of the TG protein, is proposed as a candidate for IFN-type
I gene regulation.