THE AZOOSPERMIA FACTOR (AZF) OF THE HUMAN Y-CHROMOSOME IN YQ11 - FUNCTION AND ANALYSIS IN SPERMATOGENESIS

Different Y mutations in Yq11 occurring ne novo in sterile males were first described 19 years ago. Since the phenotype of the patients was always associated with azoospermia or severe oligospermia, it was post ulated that these mutations interrupt a Y spermatogenesis locus in the euchromatic Y region (Yq11) called azoospermia factor (AZF). Recently , it became possible to map AZF mutations to different subregions in Y q11 by molecular deletion mapping. This indicated that azoospermia is possibly caused by more than one Y gene in Yq11 and the Yq11 chromatin structure. The frequency of AZF mutations in idiopathic sterile males (5-20%) may indicate a need for a general screening programme for its analysis in infertility clinics.